Comparison of Maternal Serum Screening Test Efficacy for Down Syndrome / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 721-731, 1997.
Article
em Ko
| WPRIM
| ID: wpr-129578
Biblioteca responsável:
WPRO
ABSTRACT
Maternal serum alpha-feto protein(MSAFP) screening test has provided high sensitivity and specificity in detecting neural tube defects(NTD). Approximately 80~90% of NTD can be identified by this screening test.Prospective studies have shown that low levels of MSAFP can be used for Down syndrome screening test, but the detection rate for Down syndrome in combination with age is only 20% in younger women, making this screening test relatively insensitive. However recently some studies have suggested that the triple marker test with MSAFP, unconjugated estriol, beta-human chorionic gonadotropin achieved higher detection rate for Down syndrome. The purpose of present study is to compare the positive predictive values of both MSAFP and Triple test. We had 6,436 cases of MSAFP test during the year of 1994 and 7,077 cases for triple test during the year of 1995. We analyzed data with positive results by screening both tests, since our purpose is to compare positive value. The number of positive results were 290(triple test) and 206(AFP) respectively. With this study, we concluded that positive predictive value of triple marker test is 4.17 times greater than of the MSAP test.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Programas de Rastreamento
/
Sensibilidade e Especificidade
/
Síndrome de Down
/
Estriol
/
Tubo Neural
/
Gonadotropina Coriônica
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Screening_studies
Limite:
Female
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
1997
Tipo de documento:
Article