Forkhead box O-class 1 and Forkhead box G1 as Prognostic Markers for Bladder Cancer
Journal of Korean Medical Science
; : 468-473, 2009.
Article
em En
| WPRIM
| ID: wpr-134349
Biblioteca responsável:
WPRO
ABSTRACT
Forkhead box O-class 1 (FOXO1) is a key regulator of glucose homeostasis, cell-cycle progression, and apoptosis. Its functions are modulated by forkhead box G1 (FOXG1), which acts as a transcriptional repressor with oncogenic potential. Real-time PCR and immunohistochemical staining were performed in 174 primary bladder cancer specimens and 21 normal bladder mucosae to evaluate these genes. FOXO1 and FOXG1 mRNA expression in cancer tissues were higher than in normal mucosae (each P<0.001). FOXO1 mRNA levels were significantly higher in samples of non-progressed patients (P<0.001), but FOXG1 were enhanced in those of progressed patients (P=0.019). On univariate analysis, FOXO1 mRNA expression was significantly associated with grade, stage, recurrence, progression and survival (each P<0.05). On multivariate analysis, increased FOXO1 mRNA expression was associated with both reduced disease progression (odds ratio [OR], 0.367; 95% confidence interval [CI], 0.163-0.826, P=0.015) and enhanced disease-free survival (OR, 3.262; 95% CI, 1.361-7.820, P=0.008). At a median follow-up of 33 months (range 2 to 156), the patients with a high FOXO1 mRNA expression had a significantly prolonged survival (P=0.001). Immunohistochemical findings of FOXO1 were generally concordant with mRNA expression levels. In conclusion, FOXO1 may be a promising marker for predicting progression in human bladder cancers.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Prognóstico
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Neoplasias da Bexiga Urinária
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RNA Mensageiro
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Biomarcadores Tumorais
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Razão de Chances
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Curva ROC
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Intervalo Livre de Doença
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Fatores de Transcrição Forkhead
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Estadiamento de Neoplasias
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Proteínas do Tecido Nervoso
Tipo de estudo:
Etiology_studies
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Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2009
Tipo de documento:
Article