Association of the ACE gene polymorphism with the progression of autosomal dominant polycystic kidney disease
Journal of Korean Medical Science
; : 431-435, 2000.
Article
em En
| WPRIM
| ID: wpr-135353
Biblioteca responsável:
WPRO
ABSTRACT
Renin-angiotensin system is considered important in the genesis of hypertension and development of end-stage renal disease (ESRD) in autosomal dominant polycystic kidney disease (ADPKD). The angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been associated with susceptibility to the development of some renal diseases. We investigated the association of ACE gene polymorphism with the progression to hypertension and ESRD in 108 patients with ADPKD. The ACE I/D polymorphism was amplified with the flanking primers by polymerase chain reaction. In patients genotyped for ACE gene polymorphism, the frequencies of DD (15+ACU-), ID (51+ACU-) and II (34+ACU-) genotypes were similar to those of the general population. Of the 108 patients, 64 (59+ACU-) developed hypertension and 24 (22+ACU-) reached ESRD at the time of study. The prevalence of hypertension was not significantly different among the three genotypes. The mean renal survival time was 53-6 yr in II genotype, 5510 yr in ID genotype and 529 yr in DD genotype which was not significantly different among them. Cumulative renal survival was not significantly different either. There was no association of ACE gene polymorphism with the prevalence of hypertension and renal survival in ADPKD. We suggest that ACE I/D polymorphism is not an important modifying gene in the progression of ADPKD.
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Índice:
WPRIM
Assunto principal:
Estudo Comparativo
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Reação em Cadeia da Polimerase
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Prevalência
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Rim Policístico Autossômico Dominante
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Peptidil Dipeptidase A
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Progressão da Doença
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Predisposição Genética para Doença
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Genótipo
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Hipertensão Renal
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Falência Renal Crônica
Tipo de estudo:
Prevalence_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2000
Tipo de documento:
Article