Your browser doesn't support javascript.
loading
Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a
Article em En | WPRIM | ID: wpr-138512
Biblioteca responsável: WPRO
ABSTRACT
Enterovirus 71 (EV71) is the predominant cause of hand, foot and mouth disease (HFMD). The antiviral activity of hederasaponin B from Hedera helix against EV71 subgenotypes C3 and C4a was evaluated in vero cells. In the current study, the antiviral activity of hederasaponin B against EV71 C3 and C4a was determined by cytopathic effect (CPE) reduction method and western blot assay. Our results demonstrated that hederasaponin B and 30% ethanol extract of Hedera helix containing hederasaponin B showed significant antiviral activity against EV71 subgenotypes C3 and C4a by reducing the formation of a visible CPE. Hederasaponin B also inhibited the viral VP2 protein expression, suggesting the inhibition of viral capsid protein synthesis.These results suggest that hederasaponin B and Hedera helix extract containing hederasaponin B can be novel drug candidates with broad-spectrum antiviral activity against various subgenotypes of EV71.
Assuntos
Palavras-chave
Texto completo: 1 Índice: WPRIM Assunto principal: Células Vero / Western Blotting / Enterovirus / Hedera / Proteínas do Capsídeo / Etanol / Doença de Mão, Pé e Boca Idioma: En Revista: Biomolecules & Therapeutics Ano de publicação: 2014 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Células Vero / Western Blotting / Enterovirus / Hedera / Proteínas do Capsídeo / Etanol / Doença de Mão, Pé e Boca Idioma: En Revista: Biomolecules & Therapeutics Ano de publicação: 2014 Tipo de documento: Article