Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a
Biomolecules & Therapeutics
; : 41-46, 2014.
Article
em En
| WPRIM
| ID: wpr-138513
Biblioteca responsável:
WPRO
ABSTRACT
Enterovirus 71 (EV71) is the predominant cause of hand, foot and mouth disease (HFMD). The antiviral activity of hederasaponin B from Hedera helix against EV71 subgenotypes C3 and C4a was evaluated in vero cells. In the current study, the antiviral activity of hederasaponin B against EV71 C3 and C4a was determined by cytopathic effect (CPE) reduction method and western blot assay. Our results demonstrated that hederasaponin B and 30% ethanol extract of Hedera helix containing hederasaponin B showed significant antiviral activity against EV71 subgenotypes C3 and C4a by reducing the formation of a visible CPE. Hederasaponin B also inhibited the viral VP2 protein expression, suggesting the inhibition of viral capsid protein synthesis.These results suggest that hederasaponin B and Hedera helix extract containing hederasaponin B can be novel drug candidates with broad-spectrum antiviral activity against various subgenotypes of EV71.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Células Vero
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Western Blotting
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Enterovirus
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Hedera
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Proteínas do Capsídeo
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Etanol
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Doença de Mão, Pé e Boca
Idioma:
En
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2014
Tipo de documento:
Article