Optimal Effect-Site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway Removal during Emergence
Yonsei Medical Journal
; : 529-534, 2015.
Article
em En
| WPRIM
| ID: wpr-141606
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
This randomized, controlled, double-blind study was designed to determine the optimal dose of remifentanil for preventing complications associated with the removal of a laryngeal mask airway (LMA) without delaying emergence. MATERIALS ANDMETHODS:
This study randomly assigned 128 patients to remifentanil effect-site concentrations (Ce) of 0 ng/mL (group R0), 0.5 ng/mL (group R0.5), 1.0 ng/mL (group R1.0), and 1.5 ng/mL (group R1.5) during emergence. The emergence and recovery profiles were recorded. Adverse events such as coughing, airway obstruction, breath-holding, agitation, desaturation, nausea, and vomiting were also evaluated.RESULTS:
The number of patients with respiratory complications such as coughing and breath-holding was significantly lower in the R1.0 and R1.5 groups than in the R0 group (p<0.05). Emergence agitation also decreased in the R1.0 and R1.5 groups (p<0.0083). The time to LMA removal was significantly longer in the R1.5 group than in the other groups (p<0.05).CONCLUSION:
Maintaining a remifentanil Ce of 1.0 ng/mL during emergence may suppress adverse events such as coughing, breath-holding, and agitation following the removal of LMA without delayed awakening.Palavras-chave
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Índice:
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Assunto principal:
Piperidinas
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Complicações Pós-Operatórias
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Agitação Psicomotora
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Vômito
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Infusões Intravenosas
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Período de Recuperação da Anestesia
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Método Duplo-Cego
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Máscaras Laríngeas
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Anestésicos Intravenosos
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Tosse
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Yonsei Medical Journal
Ano de publicação:
2015
Tipo de documento:
Article