Diagnostic value of procalcitonin and CRP in critically ill patients admitted with suspected sepsis
Journal of Dental Anesthesia and Pain Medicine
; : 135-140, 2015.
Article
em En
| WPRIM
| ID: wpr-143035
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Identifying early markers of septic complications can aid in the diagnosis and therapeutic management of hospitalized patients. In this study, the utility of procalcitonin (PCT) vs. C-reactive protein (CRP) as early markers of sepsis was compared.METHODS:
A series of 2,697 consecutive blood samples was collected from hospitalized patients and serum PCT and CRP levels were measured. Patients were categorized by PCT level as follows 10 ng/ml. Diagnostic utility was analyzed by receiver operating characteristic (ROC) curves.RESULTS:
Mean CRP levels varied among the five PCT categories at 0.31 ± 2.87, 5.65 ± 6.26, 13.78 ± 8.01, 12.15 ± 10.16, and 17.77 ± 10.59, respectively (P < 0.05). PCT and CRP differed between positive and negative blood culture groups (PCT 15.9 vs. 4.78 mg/dl; CRP 11.5 ng/ml vs. 9.57 ng/ml; P < 0.05). The areas under the ROC curves (PCT, 95% confidence interval [CI] 0.743, range 0.698-0.789 at a threshold of 0.5 ng/ml; CRP, 95% CI 0.540, range 0.478-0.602 at a threshold of 8 mg/l) differed for PCT and CRP (P < 0.05).CONCLUSIONS:
Therefore, PCT is a reliable marker for sepsis diagnosis and is more relevant than CRP in patients with a positive blood culture. These findings can be useful for the treatment of critically ill sepsis patients.Palavras-chave
Texto completo:
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Índice:
WPRIM
Assunto principal:
Proteína C-Reativa
/
Curva ROC
/
Estado Terminal
/
Sepse
/
Diagnóstico
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Journal of Dental Anesthesia and Pain Medicine
Ano de publicação:
2015
Tipo de documento:
Article