Beneficial effects of melatonin on stroke-induced muscle atrophy in focal cerebral ischemic rats / 한국실험동물학회지
Laboratory Animal Research
; : 47-54, 2012.
Article
em En
| WPRIM
| ID: wpr-145353
Biblioteca responsável:
WPRO
ABSTRACT
Muscle atrophy is the result of two opposing conditions that can be found in pathological or diseased muscles: an imbalance in protein synthesis and degradation mechanisms. Thus, we investigated whether exogenous melatonin could regulate muscle components in stroke-induced muscle atrophy in rats. Comparing muscle phenotypes, we found that long-term melatonin administration could influence muscle mass. Muscle atrophy-related genes, including muscle atrophy F-box (MAFbx) and muscle ring finger 1 (MuRF1) were significantly down-regulated in melatonin-administered rats in the gastrocnemius. However, only MAFbx at the mRNA level was attenuated in the soleus of melatonin-administered rats. Insulin-like growth factor-1 receptor (IGF-1R) was significantly over-expressed in melatonin-administered rats in both the gastrocnemius and soleus muscles. Comparing myosin heavy chain (MHC) components, in the gastrocnemius, expression of both slow- and fast-type isoforms were significantly enhanced in melatonin-administered rats. These results suggest that long-term exogenous melatonin-administration may have a prophylactic effect on muscle atrophy through the MuRF1/MAFbx signaling pathway, as well as a potential therapeutic effect on muscle atrophy through the IGF-1-mediated hypertrophic signaling pathway in a stroke animal model.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fenótipo
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RNA Mensageiro
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Atrofia Muscular
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Cadeias Pesadas de Miosina
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Isoformas de Proteínas
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Acidente Vascular Cerebral
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Modelos Animais
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Dedos
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Melatonina
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Músculos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Laboratory Animal Research
Ano de publicação:
2012
Tipo de documento:
Article