Expression of P-glycoprotein and p53 Protein in Stage IV Hepatocellular Carcinoma Treated with Systemic Chemotherapy / 대한간학회지
The Korean Journal of Hepatology
; : 459-466, 2001.
Article
em Ko
| WPRIM
| ID: wpr-146383
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is a drug-resistant tumor. The expression of a multidrug resistant gene, P-glycoprotein (P-gp) is a major mechanism of drug resistance. The aims of our study were, firstly, to observe the expression rate of P-gp in HCC tissue obtained by percutaneous fine needle aspiration (PCNA) from stage IV HCC patients; secondly to examine the association between P-gp and chemotherapeutic response; and finally to investigate the correlation between p53 protein expression and P-gp expression. Subjects and METHODS: We studied 29 cases of stage IV HCC treated by systemic chemotherapy. Expression of P-gp and p53 were evaluated by immunohistochemical staining of HCC tissue with human monoclonal antibody, JSB-1 (Anti P-gp) and DO-7 (Anti p53), respectively. We analyzed the results of immunohistochemical staining of HCC tissues of the patients in relation to chemotherapeutic response and other clinical characteristics. RESULTS: The expression rate of P-gp was 27.6%. Partial response to anti-cancer chemotherapy was observed in 16.7% of the patients. Although we could not see a statistically significant association between P-gp expression and chemotherapeutic response, none of the responsive patients showed P-gp expression. p53 protein expression was found in 45% of the patients. There was no significant correlation between p53 protein expression and P-gp expression. CONCLUSIONS: Although the number of our study subjects was small, chemotherapy- responsive patients didn't show P-gp expression. P-gp expression might be used as a predictor of response to potentially toxic anti-cancer chemotherapy in HCC patients. Further study is warranted to confirm our results.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Resistência a Medicamentos
/
Carcinoma Hepatocelular
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Membro 1 da Subfamília B de Cassetes de Ligação de ATP
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Biópsia por Agulha Fina
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Tratamento Farmacológico
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2001
Tipo de documento:
Article