Expression of Glucagon-Like Peptide-1 Receptor in Papillary Thyroid Carcinoma and Its Clinicopathologic Significance
Endocrinology and Metabolism
; : 536-544, 2014.
Article
em En
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| ID: wpr-14699
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ABSTRACT
BACKGROUND:
Incretin-based therapies are rapidly becoming one of the main glycemic control strategies in diabetes. Considering the large numbers of papillary thyroid carcinomas (PTCs) and possible effects of glucagon-like peptide-1 (GLP-1) on cell proliferation, the expression of GLP-1 receptor (GLP-1R) in PTC is likely to have clinical significance. We performed this study to evaluate the expression of GLP-1R in PTC and the clinical meaning of GLP-1R expression in PTC.METHODS:
Fifty-six cases of PTC, four cases of medullary thyroid cancer (MTC), seven cases of nodular hyperplasia and 56 normal thyroid tissue samples were selected for immunostaining for GLP-1R. Clinical parameters were obtained by retrospective review of medical records.RESULTS:
Immunohistochemical staining for GLP-1R showed immunoreactivity in 18 of 56 cases of PTC (32.1%). All four cases of MTC exhibited cytoplasmic GLP-1R expression. Nodular hyperplasia exhibited immunoreactivity in two of seven cases (28.6%). All normal thyroid follicular cells showed negative immunoreactivity. In univariable and multivariable analyses, tumor multifocality was negatively correlated with GLP-1R expression. Extrathyroidal extension showed positive association with GLP-1R expression that was almost significant. Sex, age, tumor size, and lymph node metastasis were not significantly associated with GLP-1R expression.CONCLUSION:
Some parts of PTC tissues express GLP-1R, and GLP-1R expression in PTC was negatively correlated with tumor multifocality. The long-term influence of pharmacologically increased GLP-1 on thyroid follicular cells and development and progression of tumors originating from thyroid follicular cells should be investigated.Palavras-chave
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Assunto principal:
Glândula Tireoide
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Neoplasias da Glândula Tireoide
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Prontuários Médicos
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Estudos Retrospectivos
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Citoplasma
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Proliferação de Células
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Peptídeo 1 Semelhante ao Glucagon
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Receptor do Peptídeo Semelhante ao Glucagon 1
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Hiperplasia
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Linfonodos
Tipo de estudo:
Observational_studies
Idioma:
En
Revista:
Endocrinology and Metabolism
Ano de publicação:
2014
Tipo de documento:
Article