Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-alpha/beta at the Initial Stage of Influenza A Virus (H3N2) Infection
Immune Network
; : 70-74, 2013.
Article
em En
| WPRIM
| ID: wpr-147330
Biblioteca responsável:
WPRO
ABSTRACT
L-ascorbic acid (vitamin C) is one of the well-known anti-viral agents, especially to influenza virus. Since the in vivo anti-viral effect is still controversial, we investigated whether vitamin C could regulate influenza virus infection in vivo by using Gulo (-/-) mice, which cannot synthesize vitamin C like humans. First, we found that vitamin C-insufficient Gulo (-/-) mice expired within 1 week after intranasal inoculation of influenza virus (H3N2/Hongkong). Viral titers in the lung of vitamin C-insufficient Gulo (-/-) mice were definitely increased but production of anti-viral cytokine, interferon (IFN)-alpha/beta, was decreased. On the contrary, the infiltration of inflammatory cells into the lung and production of pro-inflammatory cytokines, tumor necrosis factor (TNF)-alpha and interleukin (IL)-alpha/beta, were increased in the lung. Taken together, vitamin C shows in vivo anti-viral immune responses at the early time of infection, especially against influenza virus, through increased production of IFN-alpha/beta.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Orthomyxoviridae
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Vírus da Influenza A
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Ácido Ascórbico
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Vitaminas
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Citocinas
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Interleucinas
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Interferons
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Fator de Necrose Tumoral alfa
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Mustelidae
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Influenza Humana
Limite:
Animals
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Humans
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2013
Tipo de documento:
Article