A Pilot Study of Bortezomib in Korean Patients with Relapsed or Refractory Myeloma
Journal of Korean Medical Science
; : 598-602, 2005.
Article
em En
| WPRIM
| ID: wpr-147620
Biblioteca responsável:
WPRO
ABSTRACT
Recent clinical trials showed that bortezomib, a novel proteasome inhibitor, had therapeutic activity in multiple myeloma. However, there was no data about the feasibility of bortezomib in Korean patients. We performed a pilot study of bortezomib in patients with relapsed or refractory myeloma (1.3 mg/m2 twice weekly for 2 week in a 3-week cycle). Seven patients were enrolled. The median age of patients was 59 yr. All patients previously received VAD (vincristine, doxorubicin and dexamethasone) and thalidomide chemotherapy. Three patients previously received alkylator-containing chemotherapy and 4 patients, autologous stem cell transplantation. Bortezomib monotherapy resulted in 3 partial remissions (43%), 3 no changes (43%) and 1 progressive disease (14%). One patient who had no response to bortezomib monotherapy experienced partial remission after addition of dexamethasone to bortezomib. The most common serious toxicity was thrombocytopenia (grade 3/4, 10 of 20 cycles (50%)) and grade 3 peripheral neuropathy was developed in 2 of 20 cycles (10%). Drug-related adverse event led to discontinuation of bortezomib in 1 patient. There was no treatment related mortality. Overall, bortezomib seems to be effective and feasible. Conduction of larger clinical studies on Korean patients is necessary to characterize clinical efficacy and safety of bortezomib more precisely.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Pirazinas
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Trombocitopenia
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Fatores de Tempo
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Ácidos Borônicos
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Dexametasona
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Protocolos de Quimioterapia Combinada Antineoplásica
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Análise de Sobrevida
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Projetos Piloto
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Progressão da Doença
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Resistencia a Medicamentos Antineoplásicos
Limite:
Aged
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2005
Tipo de documento:
Article