Physiologic and pathologic experimental models for studying cholangiocytes / 대한간학회지
The Korean Journal of Hepatology
; : 139-149, 2008.
Article
em Ko
| WPRIM
| ID: wpr-149508
Biblioteca responsável:
WPRO
ABSTRACT
Cholangiocytes (epithelial cells lining the intra- and extrahepatic bile ducts) and hepatocytes are two major components of liver epithelia. Although cholangiocytes are less numerous than hepatocytes, they are involved in both bile secretion and diverse cellular processes such as cell-cycle phenomena, cell signaling, and interactions with other cells, matrix components, foreign organisms, and xenobiotics. Cholangiocytes are also targets in several human diseases including cholangiocarcinoma, primary sclerosing cholangitis, autoimmune cholangitis, and vanishing bile-duct syndrome. The rapid advances in experimental biology technologies are greatly expanding interest in and knowledge of the physiology and pathophysiology of cholangiocytes. This review focuses on the progress of in vivo and in vitro experimental models in elucidating the physiologic functions of cholangiocytes and the pathophysiology of various cholangiopathies. The following aspects are reviewed: isolation of cholangiocytes from the liver and their heterogeneity, various culture systems, establishment of cholangiocyte cell lines, isolation and usage of intrahepatic bile-duct units, three-dimensional modeling of the bile duct, experimental models for inducing cholangiocyte proliferation, and various cholangiopathies such as cholangiocarcinoma, primary sclerosing cholangitis, and autoimmune cholangitis.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Doenças dos Ductos Biliares
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Ductos Biliares
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Imageamento Tridimensional
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Modelos Animais
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Modelos Animais de Doenças
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Células Epiteliais
Limite:
Animals
/
Humans
Idioma:
Ko
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2008
Tipo de documento:
Article