Eradication Rate by Duration of Third-line Rescue Therapy with Levofloxacin after Helicobacter pylori Treatment Failure in Clinical Practice / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 260-264, 2016.
Article
em En
| WPRIM
| ID: wpr-149530
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
This study evaluated the eradication rate of levofloxacin-containing rescue therapy by treatment duration in patients in whom previous first- and second-line treatment failed.METHODS:
Fifty-five patients with persistent Helicobacter pylori infection after first-line therapy and second-line therapy were studied in a single referral academic center. We compared the eradication rates by the treatment duration of third-line therapy.RESULTS:
Of 55 patients, 12 (21.8%) received rescue therapy for seven days, 24 (43.6%) received rescue therapy for 10 days, and 19 (34.5%) received rescue therapy for 14 days. The eradication rates of therapy with levofloxacin were 65.5% in the 55 enrolled patients and 73.5% in the 49 patients who underwent follow-up testing. In cases where follow-up testing was performed, the eradication rate of 7-day therapy was 58.3%, of 10-day 68.2%, and of 14-day therapy 93.3%. Eradication rate of 14-day therapy was higher than 7-day (p=0.06) and 10-day (p=0.108), but chance could not be ruled out in the difference among groups.CONCLUSIONS:
This study showed somewhat increasing of H. pylori eradication rate by extending the duration of levofloxacin-containing rescue therapy to 14 days.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Encaminhamento e Consulta
/
Seguimentos
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Helicobacter pylori
/
Helicobacter
/
Falha de Tratamento
/
Levofloxacino
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2016
Tipo de documento:
Article