Durability of a sustained virologic response in combination therapy with interferon/peginterferon and ribavirin for chronic hepatitis C / 대한간학회지
The Korean Journal of Hepatology
; : 70-79, 2009.
Article
em Ko
| WPRIM
| ID: wpr-149673
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUNDS/AIMS: The ultimate goal of antiviral therapy using interferon/pegylated interferon combined with ribavirin in chronic C-viral hepatitis is to achieve a sustained virologic response (SVR). Several studies have shown that the reappearance rate of hepatitis C virus (HCV) RNA in serum after the achievement of an SVR is less than 1%; the durability of an SVR in Korean patients is not known. The aim of this study was to determine the durability of the virologic response in chronic hepatitis C patients with an SVR to antiviral therapy. METHODS: A total of 156 patients who were treated successfully with interferon/peginterferon and ribavirin were evaluated retrospectively. Patients received either subcutaneous conventional interferon alpha 3x10(6) units three times a week or subcutaneous pegylated interferon (alpha-2a: 180 microgram, alpha-2b: 80-100 microgram) once a week in combination with ribavirin at 600-1,200 mg daily (depending on body weight). Patients with HCV genotype 1 were treated for 48 weeks, whereas those with non-genotype 1 were treated for 24 weeks. RESULTS: Eighty-two patients underwent treatment with conventional interferon and ribavirin, whereas 74 patients were treated with pegylated interferon and ribavirin. An SVR was achieved in 73 patients (73/156, 46.8%). HCV RNA reappeared in eight patients (8/73, 11.0%; detected by qualitative PCR), including one patient with persistent viremia (1/73, 1.4%). CONCLUSIONS: Reappearance of HCV RNA after earlier achievement of an SVR might appear more frequently than previously reported. Close follow-up of these patients is recommended and the implication of temporary viremia should be determined in the future.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Antivirais
/
Polietilenoglicóis
/
Recidiva
/
Ribavirina
/
Viremia
/
RNA Viral
/
Estudos Retrospectivos
/
Interferon-alfa
/
Hepatite C Crônica
/
Quimioterapia Combinada
Tipo de estudo:
Observational_studies
/
Qualitative_research
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Ko
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2009
Tipo de documento:
Article