The Effect of Pomegranate on Depression, Anxiety, and Food Intake in Ovariectomized Rats / 대한폐경학회지
The Journal of Korean Society of Menopause
; : 39-45, 2010.
Article
em Ko
| WPRIM
| ID: wpr-152928
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: To determine whether or not pomegranate extract can affect depression, anxiety, and food intake in ovariectomized rats. METHODS: Seventy-nine female Sprague-Dawley rats were divided into six groups: A, no operation and no drug intake; B, sham operation and distilled water; C, ovariectomy and distilled water; D, ovariectomy and 10% dilute pomegranate extract; E, ovariectomy and 20% dilute pomegranate extract; and F, ovariectomy and 40% dilute pomegranate extract. Beginning 2 days after surgery, drugs were administrated for 4 weeks. After that, the rats were subjected to the elevated plus maze (EPM) test and forced swim test (FST). RESULTS: The 10% pomegranate extract had a lower % closed arm entry frequency in the EPM test. A pomegranate dose-dependent decrease in the duration of immobility duration in FST was shown. Pomegranate did not reverse ovariectomy-related hyperphagia and weight gain. CONCLUSION: Pomegranate extract improved depression and anxiety in a postmenopausal model with ovariectomized rats.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Ansiedade
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Braço
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Ovariectomia
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Hiperfagia
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Salicilamidas
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Ratos Sprague-Dawley
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Lythraceae
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Depressão
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Ingestão de Alimentos
Limite:
Animals
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Female
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Humans
Idioma:
Ko
Revista:
The Journal of Korean Society of Menopause
Ano de publicação:
2010
Tipo de documento:
Article