Clinical Characteristics of Late-onset Rheumatoid Arthritis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
; : 291-298, 2006.
Article
em Ko
| WPRIM
| ID: wpr-153042
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
Late-onset rheumatoid arthritis (LORA) refereed as the subset of rheumatoid arthritis with age of onset over 60 years old, seems to differ from younger onset disease (YORA) by more equal sex distribution, a higher frequency of abrupt disease onset, more large joints involvement, more extraarticular manifestation, erythrocyte sedimentation test (ESR), and less rheumatoid factor (RF) positivity. We need data of LORA in Korea because of lack of data.METHODS:
Two hundred and forty-two patients were studied retrospectively. We compared the difference with clinical manifestation, disease activity markers, RF, ANA, and radiologic changes between LORA and YORA. Sums of ESR and C-reactive protein (CRP) during first year after diagnosis were calculated through area under curve. Radiologic joint damages were evaluated using modified Sharp score.RESULTS:
The gender ratio (female/male) was 1.54 in LORA and 6.43 in YORA (p<0.001). The duration of the diagnosis was longer in LORA than in YORA (25.2+/-27.0 months, 18.5+/-22.2 months, p=0.048). Tender and swollen joint, and involvement of joints were not different in the groups. ESR, CRP, platelet, and RF were higher with LORA. Sums of ESR and CRP were higher in LORA than in YORA (403.7+/-252.2 mm/hr, 25.6+/-41.1 mg/dL vs 281.4+/-201.3, 12.0+/-15.0). There was no difference of modified Sharp score in both groups.CONCLUSION:
The LORA has an equal gender ratio, longer morning stiffness and disease duration, and higher levels of RF, platelet, ESR, CRP, and summation of ESR and CRP, which suggests that LORA may have poorer prognosis than YORA.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Artrite Reumatoide
/
Prognóstico
/
Fator Reumatoide
/
Plaquetas
/
Sedimentação Sanguínea
/
Proteína C-Reativa
/
Estudos Retrospectivos
/
Distribuição por Sexo
/
Idade de Início
/
Área Sob a Curva
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
The Journal of the Korean Rheumatism Association
Ano de publicação:
2006
Tipo de documento:
Article