STAT6 Expression and IL-13 Production in Association with Goblet Cell Hyperplasia and Worm Expulsion of Gymnophalloides seoi from C57BL/6 Mice
The Korean Journal of Parasitology
; : 589-594, 2013.
Article
em En
| WPRIM
| ID: wpr-155350
Biblioteca responsável:
WPRO
ABSTRACT
In intestinal helminth infections, Th2 immune respones are generally associated with mucin secretion for worm expulsion from the host intestine. In particular, IL-4 and IL-13 are the important cytokines related with intestinal mucus production via STAT6 signalling in nematode infections. However, this perspective has never been studied in Gymnophalloides seoi infection. The present study aimed to observe the STAT6 signalling and cytokine responses in C57BL/6 mice, a mouse strain resistant to infection with this trematode. The results showed that worm expulsion occurred actively during days 1-2 post-infection (PI), when goblet cells began to proliferate in the small intestine. The STAT6 gene expression in the mouse spleen became remarkable from day 2 PI. Moreover, G. seoi infection induced a significant increase of IL-13 from day 4 PI in the spleen of infected mice. Our results suggested that goblet cell hyperplasia and worm expulsion in G. seoi-infected mice should be induced by STAT6 signalling, in which IL-13 may be involved as a dominant triggering cytokine.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Baço
/
Trematódeos
/
Triquinelose
/
Transdução de Sinais
/
Interleucina-4
/
Organismos Livres de Patógenos Específicos
/
Interleucina-13
/
Células Caliciformes
/
Crassostrea
/
Fator de Transcrição STAT6
Limite:
Animals
Idioma:
En
Revista:
The Korean Journal of Parasitology
Ano de publicação:
2013
Tipo de documento:
Article