Clinical and Biochemical Parameters of Nutrition to Predict Hepatic Encephalopathy in Cirrhotic Patients / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 44-51, 2006.
Article
em Ko
| WPRIM
| ID: wpr-157130
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Protein-calorie malnutrition is a common complication in cirrhosis. Protein restriction for the treatment of hepatic encephalopathy (HE) may cause disease progression and poor prognosis. Therefore, we evaluated important clinical parameters for nutritional state in cirrhotic patients with or without HE to predict the development of HE.METHODS:
Twenty-two cirrhotic patients were divided into two groups; group A-13 patients without HE and group B-9 patients with HE. Clinical and biochemical parameters, serum proteins {serum albumin, insulin-like growth factor-1 (IGF-1), transferrin, leptin, etc}, immunologic parameters and anthropometry were measured.RESULTS:
Child-Pugh score and Model for End-stage Liver Disease (MELD) scale were higher in group B (p<0.01). After correction of various factors affecting nutritional assessment, especially of Child-Pugh score and MELD scale, leptin was higher in group B (p<0.05). There was no difference in anthropometric measurements. Transferrin correlated inversely with MELD scale in group A (p<0.01). IGF-1 correlated inversely with total lymphocyte count in group B (p<0.05). Leptin correlated with Child-Pugh scores, total lymphocyte count and mid-arm muscle cirumference in group A (p<0.05, p<0.05 and p<0.05, respectively), and correlated inversely with CD8 in group B (p<0.05).CONCLUSIONS:
Leptin level is higher in patients with HE, and further studies for parameters of nutrition to predict HE in many cirrhotic patients will be needed.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Transferrina
/
Fator de Crescimento Insulin-Like I
/
Biomarcadores
/
Antropometria
/
Encefalopatia Hepática
/
Estado Nutricional
/
Leptina
/
Cirrose Hepática
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
Ko
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2006
Tipo de documento:
Article