N-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis
Gut and Liver
; : 357-362, 2013.
Article
em En
| WPRIM
| ID: wpr-158228
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: To investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP). METHODS: Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group. The ANP model was established by a retrograde injection of 3% sodium taurocholate into the pancreatic duct. The NAC-treated group received an intravenous infusion of NAC just 2 hours before and 30 minutes after the induction of ANP. The pancreatic microvascular perfusion was measured with laser Doppler flowmetry and pancreatic samples were collected for histological examination. RESULTS: The microvascular perfusion in the NAC-treated group decreased slightly and exhibited a significant increase compared to the ANP group (p<0.01). A pathological examination revealed that edema and inflammatory infiltration decreased, and the hemorrhaging and necrosis of the pancreas were significantly reduced. CONCLUSIONS: NAC could improve pancreatic microvascular perfusion and alleviate the severity of sodium taurocholate-induced ANP, possibly representing a new therapeutic approach to prevent the progression of ANP.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pâncreas
/
Ductos Pancreáticos
/
Perfusão
/
Acetilcisteína
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Sódio
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Ácido Taurocólico
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Infusões Intravenosas
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Fator Natriurético Atrial
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Fluxometria por Laser-Doppler
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Pancreatite Necrosante Aguda
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2013
Tipo de documento:
Article