Your browser doesn't support javascript.
loading
Intermuscular Adipose Tissue Content and Intramyocellular Lipid Fatty Acid Saturation Are Associated with Glucose Homeostasis in Middle-Aged and Older Adults
Article em En | WPRIM | ID: wpr-161470
Biblioteca responsável: WPRO
ABSTRACT

BACKGROUND:

Insulin resistance is associated with the higher content of intermuscular adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of data exist in humans. This study examined associations among IMAT content, IMCL saturation, and fasting glucose concentration in middle-aged and older adults with overweight or obesity.

METHODS:

Seventy-five subjects (26 males, 49 females) were recruited and thigh muscle and IMAT were assessed using magnetic resonance imaging. Vastus lateralis tissue was acquired from a subset of nine subjects and IMCL content and saturation were assessed using nonlinear dual complex microscopy.

RESULTS:

The characteristics of the 75 subjects were as follows age 59±11 years, body mass index 30±5 kg/m², fasting glucose concentration 5.2±0.5 mmol/L, fasting insulin concentration 12.2±7.3 µU/mL, fasting homeostatic model assessment of insulin resistance (HOMA-IR) 2.9±2.0 (mean±SD). IMAT to muscle tissue (MT) volume ratio was positively associated with the saturated fatty acid to unsaturated fatty acid ratio in IMCL. IMATMT was positively associated with fasting glucose concentration and HOMA-IR. IMCL saturation was positively associated with fasting glucose concentration while muscle cell area, IMCL area, and % IMCL in muscle cell were not associated with fasting glucose concentration.

CONCLUSION:

These results indicate that higher intermuscular fat content and IMCL saturation may impact fasting glucose concentration in middle-aged and older adults with overweight or obesity. The centralization of adipose tissue in the appendicular region of the body may promote insulin resistance.
Assuntos
Palavras-chave
Texto completo: 1 Índice: WPRIM Assunto principal: Coxa da Perna / Resistência à Insulina / Imageamento por Ressonância Magnética / Índice de Massa Corporal / Tecido Adiposo / Jejum / Células Musculares / Músculo Quadríceps / Sobrepeso / Glucose Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Endocrinology and Metabolism Ano de publicação: 2017 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Coxa da Perna / Resistência à Insulina / Imageamento por Ressonância Magnética / Índice de Massa Corporal / Tecido Adiposo / Jejum / Células Musculares / Músculo Quadríceps / Sobrepeso / Glucose Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Endocrinology and Metabolism Ano de publicação: 2017 Tipo de documento: Article