The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial
Journal of Veterinary Science
; : 239-247, 2009.
Article
em En
| WPRIM
| ID: wpr-164461
Biblioteca responsável:
WPRO
ABSTRACT
Twenty-five dogs were included in a randomized, double-blind trial to assess the efficacy of doxycycline (DOX) orally administered twice a day at 4 mg/kg/day (n = 12) for the treatment of osteoarthritis of the hip. Chondroitin sulfate (CS; 525 mg/day) was used as a positive control (n = 13). Dogs were re-examined monthly for 6 months after initiation of treatment. The assessment protocol included clinical score, radiographic findings and serum osteoarthritis biomarkers. Dogs treated with DOX showed statistically significant improvements (p < 0.05) in lameness, joint mobility, pain on palpation, weight-bearing and overall score at 2, 6, 4, 4 and 4 months, respectively, after treatment. Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased (p < 0.05) at 2 and 3 months after treatment compared to pretreatment. These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fatores de Tempo
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Biomarcadores
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Osteoartrite do Quadril
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Resultado do Tratamento
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Doxiciclina
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Doenças do Cão
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Ácido Hialurônico
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Articulações
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Coxeadura Animal
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Revista:
Journal of Veterinary Science
Ano de publicação:
2009
Tipo de documento:
Article