The Expression of DNA Dependent Protein Kinase Protein in Malignant Lymphoma
Korean Journal of Pathology
; : 477-485, 2001.
Article
em Ko
| WPRIM
| ID: wpr-166947
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
DNA dependent protein kinase (DNA-PK) composed of Ku70, Ku80 and DNA-PK catalytic subunit (DNA-PKcs), plays an important role in the primary repair of break points of damaged DNA and is involved in the recombination of the V, D, and J genes. Loss of DNA-PK may lead to immunodeficiency and malignant lymphomas. This hypothesis has been supported by animal study in a Ku70 knock-out mouse model. The relationship between DNA-PK and human malignant lymphoma has not yet been studied.METHODS:
We examined the loss of DNA-PK proteins in 85 representative cases of different subtypes of malignant lymphoma. Immunohistochemical stains for DNA-PK subunits were performed on formalin-fixed and paraffin-embedded tissue sections.RESULTS:
Lymphomas demonstrated statistically significant loss of Ku70, Ku80 and DNA-PKcs. T cell lymphomas showed more loss of DNA-PK proteins in comparison with B cell lymphomas. According to the World Health Organization (WHO) classification system, both T cell lymphomas and high-grade subtypes of B cell lymphomas demonstrated similar degree of loss of DNA-PK proteins.CONCLUSIONS:
We confirmed the loss of DNA-PK proteins in malignant lymphomas through the results of our study, and the loss of these proteins seems to be more significant in high-grade lymphomas. These findings support the role of DNA-PK as a tumor suppressor gene.Palavras-chave
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Índice:
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Assunto principal:
Proteínas Quinases
/
Recombinação Genética
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Organização Mundial da Saúde
/
Linfoma não Hodgkin
/
DNA
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Genes Supressores de Tumor
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Linfoma de Células B
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Linfoma de Células T
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Classificação
/
Domínio Catalítico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Pathology
Ano de publicação:
2001
Tipo de documento:
Article