Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice
Experimental & Molecular Medicine
; : 358-364, 2003.
Article
em En
| WPRIM
| ID: wpr-171366
Biblioteca responsável:
WPRO
ABSTRACT
Glucocorticoid-induced TNF receptor (GITR) was a new member of the TNF/nerve growth factor receptor (TNFR/ NGFR) family and induced in murine T cells by dexamathasone. Recombinant soluble GITR (sGITR) induced an inflammation in peritoneal membrane and changes in spleen after i.p. injection of 3 mg/kg in C57BL/6 mice. Spleen was enlarged and percentage of neutrophils and monocytes were increased. The area of red pulp in spleen was increased, while that of white pulp was decreased after GITR injection. The thickening of membrane and neutrophil infiltration was observed in peritoneal membrane with increased myeloperoxidase activity. At later time, neutrophil infiltration moved to inside the tissue with tissue damage. GITR ligand and GITR were expressed constitutively on the surface of spleen cells and cells from peritoneal fluid. In contrast, no significant change in the spleen and in peritoneal membrane was observed in mice treated with LPS. GITR may play a role in body's inflammatory processes.
Texto completo:
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Índice:
WPRIM
Assunto principal:
Solubilidade
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Baço
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Proteínas de Transporte
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Receptores de Fator de Crescimento Neural
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Receptores do Fator de Necrose Tumoral
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Citometria de Fluxo
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Inflamação
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Injeções
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Camundongos Endogâmicos C57BL
Limite:
Animals
Idioma:
En
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2003
Tipo de documento:
Article