Serum insulin-like growth factor (IGF)-I and IGF-binding proteins in lung cancer patients
Journal of Korean Medical Science
; : 401-404, 1999.
Article
em En
| WPRIM
| ID: wpr-171453
Biblioteca responsável:
WPRO
ABSTRACT
Many studies have shown that insulin-like growth factors (IGF-I & IGF-II) are implicated in the autocrine and paracrine growth of various tumors. Alterations in serum IGFs and IGF-binding proteins (IGFBPs) profiles have been reported in lung cancer. In this study, we measured serum levels of IGF-I and IGFBPs in 41 patients with lung cancer (small cell lung cancer, SCLC, 9; non-small cell lung cancer, NSCLC, 32) by radioimmunoassay and Western ligand blot (WLB). The serum IGF-I level in patients with lung cancer was significantly lower than in controls (207.9+/-62.6 vs 281.3+/-53.9 ng/mL, p0.05). The concentration of IGFBP-3 in lung cancer was 48% of that found in controls by WLB. The serum level of IGFBP-2 was markedly elevated in patients with lung cancer compared with controls (1303.7+/-618.0 vs 696.2+/-300.5, p<0.01). However, there was no significant difference between SCLC and NSCLC groups. This result showed that serum level of IGF-I/IGFBPs may be useful markers for diagnosing and identifying tumor types in lung cancer and further studies are needed.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fator de Crescimento Insulin-Like I
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Fator de Crescimento Insulin-Like II
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Radioimunoensaio
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Carcinoma de Células Escamosas
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Adenocarcinoma
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Biomarcadores Tumorais
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Western Blotting
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Carcinoma de Células Pequenas
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Proteína 2 de Ligação a Fator de Crescimento Semelhante à Insulina
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Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
1999
Tipo de documento:
Article