Effect of the Mixture of Pueraria lobata and Sorbus commixta Extract on the Alcohol-induced Hangover in Rats
Natural Product Sciences
; : 98-103, 2015.
Article
em En
| WPRIM
| ID: wpr-182834
Biblioteca responsável:
WPRO
ABSTRACT
Pueraiae Radix (PR), Pueratia Folium (PF) and Sorbus commixta (SC) mixture, namely GS-SP (PR (1)/PF (2)/SC (0.5): v/v/v) was developed as hangover-relieving elixir and its effects on alcoholic metabolism have been investigated. The enzymatic activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) of GS-SP was shown higher than those of single treatment with PR, PL, SC, and the positive control group (YM-808). The survival rate of mouse liver cell line NCTC clone 1469 in the presence of acetaldehyde was 30.6, 22.2, and 8.7% at the GS-SP dosage level of 50, 100, and 200 microg/mL respectively. Different concentrations of 50, 100 and 200 mg/kg of GS-SP showed efficient activity for ADH and ALDH than YM-808 in rat fed with 25% ethanol. The levels of blood alcohol and acetaldehyde after oral administration of 200 mg/kg of GS-SP showed efficient activity of 11.7% and 37% than those of YM-808. These results have been supported to the potential for GS-SP to serve as an excellent potential in providing hangover relief and liver protection.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Oxirredutases
/
Álcool Desidrogenase
/
Linhagem Celular
/
Administração Oral
/
Taxa de Sobrevida
/
Células Clonais
/
Pueraria
/
Sorbus
/
Etanol
/
Alcoólicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Natural Product Sciences
Ano de publicação:
2015
Tipo de documento:
Article