The Glycated Albumin to Glycated Hemoglobin Ratio Might Not Be Associated with Carotid Atherosclerosis in Patients with Type 1 Diabetes
Diabetes & Metabolism Journal
; : 456-463, 2014.
Article
em En
| WPRIM
| ID: wpr-183759
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
The ratio of glycated albumin to glycated hemoglobin (GA/A1c) is known to be elevated in subjects with type 2 diabetes mellitus (T2DM) who had decreased insulin secretion. Additionally, the carotid intima media thickness (IMT) is greater in T2DM patients with higher GA/A1c ratios. We investigated whether increased GA/A1c ratio and IMT are also associated in type 1 diabetes mellitus (T1DM), which is characterized by lack of insulin secretory capacity.METHODS:
In this cross-sectional study, we recruited 81 T1DM patients (33 men, 48 women; mean age 44.1+/-13.0 years) who underwent carotid IMT, GA, and HbA1c measurements.RESULTS:
The mean GA/A1c ratio was 2.90. Based on these results, we classified the subjects into two groups group I (GA/A1c ratio or =2.90, n=45). Compared with group I, the body mass indexes (BMIs), waist circumferences, and IMTs were lower in group II. GA/A1c ratio was negatively correlated with BMI, urine albumin to creatinine ratio (P<0.001 for both), and both the mean and maximal IMT (P=0.001, both). However, after adjusting the confounding factors, we observed that IMT was no longer associated with GA/A1c ratio.CONCLUSION:
In contrast to T2DM, IMT was not significantly related to GA/A1c ratio in the subjects with T1DM. This suggests that the correlations between GA/A1c ratio and the parameters known to be associated with atherosclerosis in T2DM could be manifested differently in T1DM. Further studies are needed to investigate these relationships in T1DM.Palavras-chave
Texto completo:
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Índice:
WPRIM
Assunto principal:
Hemoglobinas Glicadas
/
Doenças das Artérias Carótidas
/
Índice de Massa Corporal
/
Estudos Transversais
/
Creatinina
/
Diabetes Mellitus Tipo 1
/
Diabetes Mellitus Tipo 2
/
Aterosclerose
/
Circunferência da Cintura
/
Espessura Intima-Media Carotídea
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2014
Tipo de documento:
Article