Hepatic Venous Pressure Gradient Predicts Long-Term Mortality in Patients with Decompensated Cirrhosis
Yonsei Medical Journal
; : 138-145, 2016.
Article
em En
| WPRIM
| ID: wpr-186111
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
The present study aimed to investigate the role of hepatic venous pressure gradient (HVPG) for prediction of long-term mortality in patients with decompensated cirrhosis. MATERIALS ANDMETHODS:
Clinical data from 97 non-critically-ill cirrhotic patients with HVPG measurements were retrospectively and consecutively collected between 2009 and 2012. Patients were classified according to clinical stages and presence of ascites. The prognostic accuracy of HVPG for death, survival curves, and hazard ratios were analyzed.RESULTS:
During a median follow-up of 24 (interquartile range, 13-36) months, 22 patients (22.7%) died. The area under the receiver operating characteristics curves of HVPG for predicting 1-year, 2-year, and overall mortality were 0.801, 0.737, and 0.687, respectively (all p17 mm Hg, respectively (p=0.015). In the ascites group, the mortality rates at 1 and 2 years were 3.9% and 17.6% with HVPG 17 mm Hg, respectively (p=0.044). Regarding the risk factors for mortality, both HVPG and model for end-stage liver disease were positively related with long-term mortality in all patients. Particularly, for the patients with ascites, both prothrombin time and HVPG were independent risk factors for predicting poor outcomes.CONCLUSION:
HVPG is useful for predicting the long-term mortality in patients with decompensated cirrhosis, especially in the presence of ascites.Palavras-chave
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Índice:
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Assunto principal:
Prognóstico
/
Ascite
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Pressão Venosa
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Índice de Gravidade de Doença
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Modelos de Riscos Proporcionais
/
Valor Preditivo dos Testes
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Estudos Retrospectivos
/
Fatores de Risco
/
Curva ROC
/
Falência Hepática
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Yonsei Medical Journal
Ano de publicação:
2016
Tipo de documento:
Article