Disturbance of the Glutamatergic System in Mood Disorders
Experimental Neurobiology
; : 28-35, 2014.
Article
em En
| WPRIM
| ID: wpr-187157
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WPRO
ABSTRACT
The role of glutamatergic system in the neurobiology of mood disorders draws increasing attention, as disturbance of this system is consistently implicated in mood disorders including major depressive disorder and bipolar disorder. Thus, the glutamate hypothesis of mood disorders is expected to complement and improve the prevailing monoamine hypothesis, and may indicate novel therapeutic targets. Since the contribution of astrocytes is found to be crucial not only in the modulation of the glutamatergic system but also in the maintenance of brain energy metabolism, alterations in the astrocytic function and neuroenergetic environment are suggested as the potential neurobiological underpinnings of mood disorders. In the present review, the evidence of glutamatergic abnormalities in mood disorders based on postmortem and magnetic resonance spectroscopy (MRS) studies is presented, and disrupted energy metabolism involving astrocytic dysfunction is proposed as the underlying mechanism linking altered energy metabolism, perturbations in the glutamatergic system, and pathogenesis of mood disorders.
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Assunto principal:
Transtorno Bipolar
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Encéfalo
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Neurobiologia
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Proteínas do Sistema Complemento
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Espectroscopia de Ressonância Magnética
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Astrócitos
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Ácido Glutâmico
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Transtornos do Humor
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Transtorno Depressivo Maior
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Metabolismo Energético
Idioma:
En
Revista:
Experimental Neurobiology
Ano de publicação:
2014
Tipo de documento:
Article