Effect of Probiotics on Symptoms in Korean Adults with Irritable Bowel Syndrome
Gut and Liver
; : 101-107, 2009.
Article
em En
| WPRIM
| ID: wpr-190163
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a troublesome disease. Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed a prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS. METHODS: IBS patients who met Rome III criteria were randomly assigned to receive composite probiotics or placebo. A total of 20 billion lyophilized bacteria were administered twice daily for 8 weeks. Primary outcome variables were symptom scores consisting of abdominal pain, flatulence, defecation discomfort, and sum of symptom scores. A visual analogue scale was used to quantify the severity. Secondary outcome variables consisted of the quality of life and bowel habits including defecation frequency and stool form. RESULTS: Thirty-six and 34 patients were randomized to the probiotics and placebo groups, respectively. Intention- to-treat analysis showed significant reductions in pain after 8 weeks of treatment: -31.9 and -17.7 in the probiotics and placebo groups, respectively (p=0.045). The reductions in abdominal pain, defecation discomfort, and sum of scores were more significant in 58 patients with a score of at least 3 on the baseline stool-form scale. CONCLUSIONS: Composite probiotics containing Bifidobacterium bifidum BGN4, Lactobacillus acidophilus AD031, and other species are safe and effective, especially in patients who excrete normal or loose stools.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Qualidade de Vida
/
Cidade de Roma
/
Bactérias
/
Bifidobacterium
/
Dor Abdominal
/
Estudos Prospectivos
/
Probióticos
/
Defecação
/
Síndrome do Intestino Irritável
/
Flatulência
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
Limite:
Adult
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2009
Tipo de documento:
Article