Antepartal insulin-like growth factor concentrations indicating differences in the metabolic adaptive capacity of dairy cows
J. vet. sci
; J. vet. sci;: 343-352, 2014.
Article
em En
| WPRIM
| ID: wpr-194864
Biblioteca responsável:
WPRO
ABSTRACT
Cows with different Insulin-like Growth Factor-I (IGF-I) concentrations showed comparable expression levels of hepatic growth hormone receptor (GHR). Suppressor of cytokine signaling 2 (SOCS2), could be responsible for additional inhibition of the GHR signal cascade. The aims were to monitor cows with high or low antepartal IGF-I concentrations (IGF-I(high) or IGF-I(low)), evaluate the interrelationships of endocrine endpoints, and measure hepatic SOCS2 expression. Dairy cows (n = 20) were selected (240 to 254 days after artificial insemination (AI)). Blood samples were drawn daily (day -17 until calving) and IGF-I, GH, insulin, thyroid hormones, estradiol, and progesterone concentrations were measured. Liver biopsies were taken (day 264 +/- 1 after AI and postpartum) to measure mRNA expression (IGF-I, IGFBP-2, IGFBP-3, IGFBP-4, acid labile subunit (ALS), SOCS2, deiodinase1, GHR1A). IGF-I concentrations in the two groups were different (p 0.05). Thyroxine levels and ALS expression were higher in the IGF-I(high) cows compared to IGF-I(low) cows. Estradiol concentration tended to be greater in the IGF-I(low) group (p = 0.06). It was hypothesized that low IGF-I levels are associated with enhanced SOCS2 expression although this could not be decisively confirmed by the present study.
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Assunto principal:
Progesterona
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Hormônios Tireóideos
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Gravidez
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Prenhez
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Fator de Crescimento Insulin-Like I
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Hormônio do Crescimento
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Proteína 2 de Ligação a Fator de Crescimento Semelhante à Insulina
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Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina
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Proteína 4 de Ligação a Fator de Crescimento Semelhante à Insulina
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Estradiol
Limite:
Animals
Idioma:
En
Revista:
J. vet. sci
Ano de publicação:
2014
Tipo de documento:
Article