Dietary effect of green tea extract on hydration improvement and metabolism of free amino acid generation in epidermis of UV-irradiated hairless mice / 한국영양학회지
Journal of Nutrition and Health
; : 269-276, 2016.
Article
em Ko
| WPRIM
| ID: wpr-195328
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Ultraviolet (UV) irradiation decreases epidermal hydration, which is maintained by reduction of natural moisturizing factors (NMFs). Among various NMFs, free amino acids (AA) are major constituents generated by filaggrin degradation. This experiment was conducted to determine whether or not dietary supplementation of green tea extract (GTE) in UV-irradiated mice can improve epidermal levels of hydration, filaggrin, free AAs, and peptidylarginine deiminase-3 (PAD3) expression (an enzyme involved in filaggrin degradation). METHODS: Hairless mice were fed a diet of 1% GTE for 10 weeks in parallel with UV irradiation (group UV+1%GTE). As controls, hairless mice were fed a control diet in parallel with (group UV+) or without (group UV-) UV irradiation. RESULTS: In group UV+, epidermal levels of hydration and filaggrin were lower than those in group UV-; these levels increased in group UV+1% GTE to levels similar to group UV-. Epidermal levels of PAD3 and major AAs of NMF, alanine, glycine and serine were similar in groups UV- and UV+, whereas these levels highly increased in group UV+1% GTE. CONCLUSION: Dietary GTE improves epidermal hydration by filaggrin generation and degradation into AAs.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Serina
/
Chá
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Suplementos Nutricionais
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Dieta
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Alanina
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Epiderme
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Aminoácidos
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Glicina
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Metabolismo
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Camundongos Pelados
Limite:
Animals
Idioma:
Ko
Revista:
Journal of Nutrition and Health
Ano de publicação:
2016
Tipo de documento:
Article