In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1
Experimental & Molecular Medicine
; : 193-198, 2005.
Article
em En
| WPRIM
| ID: wpr-201943
Biblioteca responsável:
WPRO
ABSTRACT
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive activity of the subset. In this study, we wanted to reveal the in vivo function of GITR in herpes simplex virus type 1 (HSV-1) infection. A single injection of anti-GITR mAb (DTA-1) immediately after viral infection significantly increased the number of CD4+ and CD8+ T cells expressing CD25, an activation surface marker, and secreting IFN-gamma. We confirmed these in vivo observations by showing ex vivo that re-stimulation of CD4+ or CD8+ T cells with a CD4+ or CD8+ T-cell-specific HSV-1 peptide, respectively, induced a significant elevation in cell proliferation and in IFN-gamma secretion. Our results indicate that GITR signals play a critical role in the T-cell immunity to HSV-1.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fragmentos de Peptídeos
/
Ativação Linfocitária
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Linfócitos T
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Linfócitos T CD4-Positivos
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Receptores de Interleucina-2
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Interferon gama
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Receptores de Fator de Crescimento Neural
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Receptores do Fator de Necrose Tumoral
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Herpesvirus Humano 1
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Linfócitos T CD8-Positivos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2005
Tipo de documento:
Article