A standardized bamboo leaf extract inhibits monocyte adhesion to endothelial cells by modulating vascular cell adhesion protein-1
Nutrition Research and Practice
; : 9-14, 2013.
Article
em En
| WPRIM
| ID: wpr-217159
Biblioteca responsável:
WPRO
ABSTRACT
Bamboo leaves (Phyllostachys pubescens Mazel ex J. Houz (Poacea)) have a long history of food and medical applications in Asia, including Japan and Korea. They have been used as a traditional medicine for centuries. We investigated the mechanism of anti-inflammatory activity of a bamboo leaf extract (BLE) on tumor necrosis factor-alpha (TNF-alpha)-induced monocyte adhesion in human umbilical vein endothelial cells (HUVECs). Exposure of HUVECs to BLE did not inhibit cell viability or cause morphological changes at concentrations ranging from 1 microg/ml to 1 mg/ml. Treatment with 0.1 mg/ml BLE caused 63% inhibition of monocyte adhesion in TNF-alpha-activated HUVECs, which was associated with 38.4% suppression of vascular cell adhesion molecule-1 expression. Furthermore, TNF-alpha-induced reactive oxygen species generation was decreased to 47.9% in BLE treated TNF-alpha-activated HUVECs. BLE (0.05 mg/ml) also caused about 50% inhibition of interleukin-6 secretion from lipopolysaccharide-stimulated monocyte. The results indicate that BLE may be clinically useful as an anti-inflammatory or anti-oxidant for human cardiovascular disease including atherosclerosis.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Ásia
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Monócitos
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Doenças Cardiovasculares
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Adesão Celular
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Sobrevivência Celular
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Interleucina-6
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Fator de Necrose Tumoral alfa
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Espécies Reativas de Oxigênio
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Molécula 1 de Adesão de Célula Vascular
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Células Endoteliais
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Nutrition Research and Practice
Ano de publicação:
2013
Tipo de documento:
Article