Chemotherapy-induced Drug Reaction due to Extravasation of Vinorelbine / 대한피부과학회지
Korean Journal of Dermatology
; : 372-376, 2016.
Article
em Ko
| WPRIM
| ID: wpr-219294
Biblioteca responsável:
WPRO
ABSTRACT
Vinorelbine, a vinca alkaloid anticancer drug, is widely used to treat various cancers. Several dermatological side effects of vinorelbine, such as acral erythema, phlebitis, and severe extravasation reactions, have been reported. Vinorelbine is categorized as non-DNA binding vesicant that undergoes high metabolism and clearance, which limits the degree of tissue injury if extravasation occurs. A 73-year-old male presented with erythematous linear patches on his left wrist and a 51-year-old male presented with erythematous eroded patches and bullae on his right forearm. Histopathologic study showed interface changes with basal vacuolar degeneration and epidermal dysmaturation. Separation of the dermis from the epidermis was observed, as well as interstitial and perivascular inflammatory infiltrates in the dermis. Both patients were being treated with vinorelbine for lung cancer. Before the onset of the skin lesions, accidental intravenous extravasation of vinorelbine had occurred. Herein, we report two cases of chemotherapy induced drug reaction due to extravasation of vinorelbine.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Flebite
/
Pele
/
Punho
/
Citocromo P-450 CYP1A1
/
Derme
/
Vinca
/
Tratamento Farmacológico
/
Epiderme
/
Eritema
/
Antebraço
Limite:
Aged
/
Humans
/
Male
Idioma:
Ko
Revista:
Korean Journal of Dermatology
Ano de publicação:
2016
Tipo de documento:
Article