Amikacin therapy for urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli
The Korean Journal of Internal Medicine
; : 156-161, 2016.
Article
em En
| WPRIM
| ID: wpr-220491
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: The number of urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) is increasing. In an outpatient setting, there are limited therapeutic options to treat ESBL-producing pathogens. We evaluated the outcomes of amikacin outpatient parenteral antibiotic therapy (OPAT) for UTIs caused by ESBL-EC in patients not pre-treated with carbapenem. METHODS: We retrospectively evaluated the outcomes of amikacin OPAT for UTIs caused by ESBL-EC. RESULTS: From November 2011 to October 2012, eight females, who could not be hospitalized for carbapenem treatment, were treated with amikacin OPAT for nine episodes of non-bacteremic ESBL-EC UTIs. Seven of the eight patients had one or more comorbidities. Of the nine UTI cases, three had symptomatic lower UTIs and six had non-bacteremic upper UTIs. In all of the cases, symptomatic and laboratory improvements were observed following amikacin OPAT. One patient showed a delayed relapse with bilateral microabscesses 3 weeks after treatment cessation; however, a clinical and microbiological cure was eventually reached. All of the patients were able to tolerate amikacin OPAT without any significant nephrotoxicity or ototoxicity. CONCLUSIONS: Amikacin OPAT represents a feasible therapeutic option for non-bacteremic UTIs caused by ESBL-EC in settings with limited resources.
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Índice:
WPRIM
Assunto principal:
Recidiva
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Fatores de Tempo
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Infecções Urinárias
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Urina
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Beta-Lactamases
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Indução de Remissão
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Esquema de Medicação
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Amicacina
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Testes de Sensibilidade Microbiana
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Estudos Retrospectivos
Tipo de estudo:
Observational_studies
Limite:
Adult
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Aged
/
Aged80
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Humans
Idioma:
En
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2016
Tipo de documento:
Article