A case of leptomeningeal metastasis from adenocarcinoma of the lung improved by treatment with Gefitinib / 대한내과학회지
Korean Journal of Medicine
; : 198-202, 2008.
Article
em Ko
| WPRIM
| ID: wpr-222776
Biblioteca responsável:
WPRO
ABSTRACT
Leptomeningeal metastasis occurs in approximately 1% of patients with non-small cell lung cancer and this is an extremely serious complication. Without treatment, the median survival of patients is 4~6 weeks. The treatment options currently available are limited and achieve only modest results. Gefitinib was recently approved for the treatment of advanced/refractory non-small cell lung cancer. In addition, there have been case reports showing activity of gefitinib against brain metastasis in non-small cell lung cancer patients. However, there is limited data on the ability of gefitinib to cross the blood-brain barrier. We report the case of a patient with leptomeningeal metastasis from adenocarcinoma of the lung that had a dramatic response to gefitinib treatment.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Quinazolinas
/
Encéfalo
/
Barreira Hematoencefálica
/
Adenocarcinoma
/
Carcinoma Pulmonar de Células não Pequenas
/
Pulmão
/
Metástase Neoplásica
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Medicine
Ano de publicação:
2008
Tipo de documento:
Article