Overview of IgG4-Related Tubulointerstitial Nephritis and Its Mimickers
Journal of Pathology and Translational Medicine
; : 26-36, 2016.
Article
em En
| WPRIM
| ID: wpr-225234
Biblioteca responsável:
WPRO
ABSTRACT
Tubulointerstitial nephritis (TIN) is the most common form of renal involvement in IgG4-related disease. It is characterized by a dominant infiltrate of IgG4-positive plasma cells in the interstitium and storiform fibrosis. Demonstration of IgG4-positive plasma cells is essential for diagnosis, but the number of IgG4-positive cells and the ratio of IgG4-positive/IgG-positive plasma cells may vary from case to case and depending on the methods of tissue sampling even in the same case. IgG4-positive plasma cells can be seen in TIN associated with systemic lupus erythematosus, Sjogren syndrome, or anti-neutrophil cytoplasmic antibody-associated vasculitis, which further add diagnostic confusion and difficulties. To have a more clear view of IgG4-TIN and to delineate differential points from other TIN with IgG4-positive plasma cell infiltrates, clinical and histological features of IgG4-TIN and its mimickers were reviewed. In the rear part, cases suggesting overlap of IgG4-TIN and its mimickers and glomerulonephritis associated with IgG4-TIN were briefly described.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Plasmócitos
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Estanho
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Fibrose
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Nefrite Lúpica
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Glomerulonefrite Membranosa
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Síndrome de Sjogren
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Diagnóstico
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Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos
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Glomerulonefrite
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Lúpus Eritematoso Sistêmico
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Journal of Pathology and Translational Medicine
Ano de publicação:
2016
Tipo de documento:
Article