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Effect of n-3 Polyunsaturated Fatty Acids on Regression of Coronary Atherosclerosis in Statin Treated Patients Undergoing Percutaneous Coronary Intervention
Korean Circulation Journal ; : 481-489, 2016.
Article em En | WPRIM | ID: wpr-227805
Biblioteca responsável: WPRO
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Statins remain the mainstay of secondary coronary artery disease (CAD) prevention, but n-3 polyunsaturated fatty acids (ω-3 PUFA) display biological effects that may also reduce the risk of atherosclerosis and CAD. However, data on the possible antiatherosclerotic benefits of adding ω-3 PUFA to statin therapy are limited. This study aimed to investigate the potential additive effects of ω-3 PUFA on regression of atherosclerosis in CAD patients receiving statin therapy and stent implantation. SUBJECTS AND

METHODS:

Seventy-four CAD patients undergoing percutaneous coronary intervention (PCI) with stent implantation were enrolled, prescribed statins, and randomly assigned to two groups n-3 group (ω-3 PUFA 3 g/day, n=38) or placebo group (placebo, n=36). All patients completed the study follow-up consisting of an intravascular ultrasound at baseline and at 12 months.

RESULTS:

There was no difference in the baseline characteristics and distribution of other medications. No significant differences were observed in primary endpoints, including changes in atheroma volume index (-12.65% vs. -8.51%, p=0.768) and percent atheroma volume (-4.36% vs. -9.98%, p=0.526), and in secondary endpoints including a change in neointimal volume index (7.84 vs. 4.94 mm3/mm, p=0.087).

CONCLUSION:

ω-3 PUFA had no definite additional effect on the regression of coronary atherosclerosis when added to statin in CAD patients undergoing PCI.
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Texto completo: 1 Índice: WPRIM Assunto principal: Doença da Artéria Coronariana / Ácidos Graxos Ômega-3 / Stents / Seguimentos / Ultrassonografia / Inibidores de Hidroximetilglutaril-CoA Redutases / Aterosclerose / Placa Aterosclerótica / Intervenção Coronária Percutânea Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Korean Circulation Journal Ano de publicação: 2016 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Doença da Artéria Coronariana / Ácidos Graxos Ômega-3 / Stents / Seguimentos / Ultrassonografia / Inibidores de Hidroximetilglutaril-CoA Redutases / Aterosclerose / Placa Aterosclerótica / Intervenção Coronária Percutânea Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Korean Circulation Journal Ano de publicação: 2016 Tipo de documento: Article