Complement-fixing abilities and IgG subclasses of autoantibodies in epidermolysis bullosa acquisita
Yonsei Medical Journal
; : 339-344, 1998.
Article
em En
| WPRIM
| ID: wpr-229297
Biblioteca responsável:
WPRO
ABSTRACT
Epidermolysis bullosa acquisita (EBA) is an autoimmune-mediated subepidermal bullous disease in which the target of the autoantibodies is type VII collagen, a major component of anchoring fibrils. The purpose of this study was to evaluate the complement-fixing abilities and IgG subclass distribution of autoantibodies in EBA, and to also attempt to investigate the relation between inflammation, complement fixation and IgG subclass distribution in EBA patients. Only 2 sera of 18 patients (11%) showed weak complement-fixing abilities. IgG1 and IgG4 were the most frequently and intensely stained IgG subclasses in EBA sera. We could not find any relationship between the clinico-pathologic types, complement-fixing abilities and IgG subclasses in EBA. These results suggested that complement activation may not be a key factor of bulla formation in EBA.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Autoanticorpos
/
Proteínas do Sistema Complemento
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Imunoglobulina G
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Epidermólise Bolhosa Adquirida
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Imunofluorescência
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Pessoa de Meia-Idade
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Yonsei Medical Journal
Ano de publicação:
1998
Tipo de documento:
Article