Changes of tumor necrosis factor, surfactant protein A, and phospholipids in bronchoalveolar lavage fluid in the development and progression of coal workers' pneumoconiosis / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 124-129, 2006.
Article
em En
| WPRIM
| ID: wpr-229716
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the alterations of biomarkers in the development and progression of coal workers' pneumoconiosis (CWP).</p><p><b>METHODS</b>The type and number of cells, and the levels of tumor necrosis factor-alpha (TNF-alpha), pulmonary surfactant protein, phospholipids and fibronectin in bronchoalveolar lavage fluid were assayed in 14 health active coal miners, 21 coal miners without CWP and 13 miners with CWP of 0/1 to 1/1.</p><p><b>RESULTS</b>Compared to active coal miners without CWP (8.23 microg/mL), TNF-alpha concentration was gradually decreased when dust exposure was stopped (5.90 microg/mL). Elevated surfactant protein A (SP-A) level and phosphatidylglycerol (PG) to phosphatidylinositol (PI) ratio were found in miners actively exposed to coal dust (6528 ng/mL for SP-A and 10. for PG/PI), and both parameters decreased when CWP progressed from CWP (0/1) (3419 microg/mL for SP-A and 5.9 for PG/PI) to CWP (1/1) (1654 microg/mL for SP-A and 5.5 for PG/PI).</p><p><b>CONCLUSION</b>Biomarkers in bronchoalveolar lavage fluid can be used to screen coal miners at high risk of developing coal workers' pneumoconiosis.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fosfolipídeos
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Pneumoconiose
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Líquido da Lavagem Broncoalveolar
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Biomarcadores
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Química
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Fator de Necrose Tumoral alfa
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Minas de Carvão
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Progressão da Doença
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Proteína A Associada a Surfactante Pulmonar
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Diagnóstico
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2006
Tipo de documento:
Article