Clinicopathological analysis on hepatitis B virus-associated glomerulonephritis in 205 patients / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate liver and kidney lesions in HBV-GN patients and relationship between them and provide evidences to make early diagnosis of HBV-GN.</p><p><b>METHODS</b>Reviewing the clinicopathological and laboratory indexes of 205 patients with HBV-GN diagnosed by renal biopsy in our hospital from September 1995 to November 2008.</p><p><b>RESULTS</b>HBV-GN account for 5.6% of all renal biopsies at the same time. Among them, 157 (76.5%) patients were male,123 (60%) was 19-45 years-old. 95 (46%) patients break out with kidney disease. HBsAg, HBeAg, HBcAg were the most common HBV makers. 102 (49.8%) patients present nephrotic syndrome, 18 (8.8%) suffered kidney dysfunction; 18 patients with hepatic cirrhosis. Patients with or without liver disfunction got no different in clinic manifestation and renal pathology. With the rising of the content of HBV-DNA in surum, the urinary protein increases. Renal data shows that membranous nephropathy(MN) was the most frequent type (60.5%).</p><p><b>CONCLUSION</b>The peak incidence of HBV-GN is in the twentieth to forth decade of life. There was a 3:1 predominance of males. Nephrotic syndrome was the most common clinic manifestation and membranous nephropathy was the most common pathology. 10% persent patisnts had loss of renal function at the time of renal biopsy. The HBV copies in serum correlated with the albuminuria. HBV-GN patients had desynchroneity lesions in kidney and liver. As the high rate of HBV infection in China, It needs to prevent the kidney damage in HBV infectious people and to elevate early diagnosis and therapy.</p>