Expression and clinical significance of serine-threonine kinase/mammalian target of rapamycin/p70 S6K signal path- way in oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 504-508, 2014.
Article
em Zh
| WPRIM
| ID: wpr-231816
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of serine-threonine kinase (Akt)/mammalian target of rapamycin (mTOR)/p70 S6K in oral squamous cell carcinoma (OSCC) and provide references for early diagnosis and prognosis evalua- tion of OSCC.</p><p><b>METHODS</b>A total of 51 cases of OSCC, 10 cases of paracancerous mucosa, and 10 cases of normal oral mucosa were collected. The expressions of Akt/mTOR/p70 S6K in these cases were detected using the SP method of immunohisto- chemistry. The correlation between their expressions in OSCC was also analyzed.</p><p><b>RESULTS</b>The positive expressions ofp-Akt, p-mTOR, and p70 S6K in OSCC were significantly higher than those in normal oral mucosa and paracancerous mucosa. The expressions of p-Akt, p-mTOR, and p70 S6K in OSCC were not correlated with age, gender, and clinical stage; by comparison, these expressions were correlated with lymph node metastasis and pathological grade. Strong positive correlations were also observed between the expressions ofp-Akt, p-mTOR, and p70 S6K in OSCC.</p><p><b>CONCLUSION</b>Akt/mTOR/p70 S6K signaling molecules exhibit active expressions in OSCC and may be implicated in the occurrence and development of OSCC.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fosforilação
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Proteínas Quinases
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Neoplasias Bucais
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Transdução de Sinais
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Proteínas Serina-Treonina Quinases
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Neoplasias de Células Escamosas
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Sirolimo
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Proteínas Quinases S6 Ribossômicas 70-kDa
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Proteínas Proto-Oncogênicas c-akt
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Serina-Treonina Quinases TOR
Tipo de estudo:
Screening_studies
Limite:
Animals
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Humans
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2014
Tipo de documento:
Article