Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 132-134, 2005.
Article
em Zh
| WPRIM
| ID: wpr-232119
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between circulating levels of insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3) and colorectal cancer.</p><p><b>METHODS</b>A meta-analysis of 6 epidemiological studies on insulin-like growth factors and risk of colorectal cancer were performed.</p><p><b>RESULTS</b>The pooled odds ratio (OR) of IGF-1 and IGFBP-3 were 1.56 (95% CI 1.14-2.13) and 0.78 (95% CI 0.43-1.44) respectively. According to the results from different measurements (enzyme-linked immunoabsorbent assay and immunoradiometric assay), the pooled OR were 1.92 and 1.23 for IGF-1, 0.46 and 1.44 for IGFBP-3 respectively.</p><p><b>CONCLUSION</b>High serum levels of IGF-1 were independent risk factors of colorectal cancer but the OR of IGFBP-3 was not statistically significant. The heterogeneity between studies on IGFBP-3 and colorectal cancer was caused by different measurements used, but there was still a need to conduct simultaneous large size study under 2 different measurements for further conclusion.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Sangue
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Fator de Crescimento Insulin-Like I
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Ensaio de Imunoadsorção Enzimática
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Radioimunoensaio
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Neoplasias Colorretais
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China
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Epidemiologia
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Fatores de Risco
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Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina
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Metabolismo
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
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Systematic_reviews
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2005
Tipo de documento:
Article