Synthesis and biological evaluation of sorafenib thiourea derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 1093-1097, 2011.
Article
em Zh
| WPRIM
| ID: wpr-233030
Biblioteca responsável:
WPRO
ABSTRACT
Basing on the market multi-target antitumor agent sorafenib, a series of sixteen 4-[4-(2-methyl-aminoacyl-pyridyl)]oxylphenyl aryl thiourea derivatives were designed and synthesized. Their structures were identified by the spectra of 1H NMR, MS and elemental analysis. The evaluation of antitumor bioactivities in vitro was done by MTT method. It was shown that the synthesized compounds had antitumor activities and compounds 1a, 1d, 1i and 1j showed better or equal antitumor activity on sorafenib.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Compostos de Fenilureia
/
Tioureia
/
Estrutura Molecular
/
Química
/
Niacinamida
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Antineoplásicos
Limite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Article