Regulatory effects of Bmi-1 gene on self-renewal of hematopoietic stem cells--review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 413-415, 2006.
Article
em Zh
| WPRIM
| ID: wpr-233578
Biblioteca responsável:
WPRO
ABSTRACT
Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. The Bmi-1 gene is a putative oncogene belonging to the Polycomb group family. Recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal of normal and leukemic stem cells. The research progress on structure and function of Bmi-1 gene, and its role in self-renewal of hematopoietic stem cells was reviewed.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fisiologia
/
Proteínas Repressoras
/
Células-Tronco Hematopoéticas
/
Proteínas Nucleares
/
Diferenciação Celular
/
Divisão Celular
/
Proteínas Proto-Oncogênicas
/
Biologia Celular
/
Complexo Repressor Polycomb 1
/
Genética
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2006
Tipo de documento:
Article