Comparison of prognostic models for patients with early-stage diffuse large B-cell lymphoma / 中华血液学杂志
Chinese Journal of Hematology
; (12): 269-272, 2016.
Article
em Zh
| WPRIM
| ID: wpr-234006
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the prognostic value of different models in patients with early-stage diffuse large B-cell lymphoma (DLBCL).</p><p><b>METHODS</b>Early-stage DLBCL patients diagnosed from January 2000 to December 2012 were analyzed retrospectively. All patients received with at least 2 cycles of immunochemotherapy R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) with or without radiotherapy. The prognostic value of international prognostic index (IPI) , revised IPI (R-IPI) and enhanced IPI (NCCN-IPI) was compared.</p><p><b>RESULTS</b>Ninety-seven cases of early-stage DLBCL were included in the study. The median age was 58 years (15-88 years) with a median follow-up of 34.7 months (range 7.3-77.4 months). The expected 5-year overall survival (OS) for entire group was 82%. There was no patient in the high risk group according to IPI or NCCN-IPI. According to IPI, the 5-year OS in the low, low intermediate, high intermediate risk groups were 95%, 38% and 60%, respectively. According to R-IPI, the 5-year OS in the very good, good, and poor risk groups were 93%, 75% and 60%, respectively. According to NCCN-IPI, the 5-year OS in the low, low intermediate, high intermediate risk groups were 92%, 85% and 29%, respectively.</p><p><b>CONCLUSION</b>NCCN-IPI would be of an ideal prognostic model for early-stage DLBCL patients.</p>
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Índice:
WPRIM
Assunto principal:
Prognóstico
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Vincristina
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Prednisona
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Protocolos de Quimioterapia Combinada Antineoplásica
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Doxorrubicina
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Estudos Retrospectivos
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Linfoma Difuso de Grandes Células B
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Ciclofosfamida
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Diagnóstico
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Anticorpos Monoclonais Murinos
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Ano de publicação:
2016
Tipo de documento:
Article