Effect of low-dose triptorelin on pituitary down-regulation for patients undergoing in vitro fertilization and embryo transfer / 中华男科学杂志
National Journal of Andrology
; (12): 367-369, 2003.
Article
em Zh
| WPRIM
| ID: wpr-238021
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of low-dose triptorelin in later luteal phase on pituitary down-regulation for patients undergoing IVF-ET.</p><p><b>METHODS</b>One hundred and twenty patients were randomly divided into 2 groups(A and B). In group A, the patients were treated with triptorelin of 0.1 mg subcutaneously daily started on day 21 of menstrual cycle for 7 days. In group B, the patients were treated with long protocol of Buserelin intranasal spray. Comparisons were made between the groups in serum concentrations of FSH, LH, E2, T, PRL and P on the third day (D3) of superovulation cycle and on the day of hCG administration, highly purified follicle-stimulating hormone (HP) dosages, and so on.</p><p><b>RESULTS</b>In group A, mean serum LH level on D3 and the day of hCG was (1.55 +/- 0.99) U/L and (2.70 +/- 1.45) U/L, E2 was (85.66 +/- 13.13) pmol/L and (5,451.31 +/- 1,900.61) pmol/L, respectively, significantly lower than those of group B (P < 0.001; P < 0.01; P < 0.05; P < 0.001). Mean HP(75 IU/Amp) dosage per treatment cycle in group A was 28.20 +/- 11.03 ampoules, significantly higher than 22.30 +/- 6.40 ampoules in group B(P < 0.001).</p><p><b>CONCLUSIONS</b>Low-dose triptorelin in later luteal phase is effective for down-regulation of pituitary and produces more suppression on endogenous LH in pituitary than Buserelin long protocol.</p>
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Assunto principal:
Fisiologia
/
Hipófise
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Sangue
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Hormônio Luteinizante
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Fertilização in vitro
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Regulação para Baixo
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Pamoato de Triptorrelina
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Transferência Embrionária
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Estradiol
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Injeções Subcutâneas
Tipo de estudo:
Guideline
Limite:
Adult
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Female
/
Humans
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2003
Tipo de documento:
Article