Relationship between Ghrelin polymorphism and serum lipoprotein levels in Han Chinese with or without coronary heart disease risk factors / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 305-308, 2008.
Article
em Zh
| WPRIM
| ID: wpr-243788
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between polymorphism of Ghrelin gene and serum levels of lipoprotein in Han Chinese with or without coronary heart disease (CHD) risk factors.</p><p><b>METHODS</b>PCR restriction fragment length polymorphism assay was used to detect the distribution of genotypes of Ghrelin gene in 225 Han Chinese (40 to 69 years-old) with CHD risk factors, 78 subjects without CHD risk factors served as normal controls. Serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein (VLDL) were measured to analyze the relationship with the polymorphism of Ghrelin gene.</p><p><b>RESULTS</b>Ghrelin genotype frequencies of AA, AG, GG (0.975, 0.025, 0.00 in control group and 0.956, 0.040, 0.004 in the high-risk group, all P > 0.05) as well as the allele frequencies of A, G (0.987, 0.013 in control group and 0.976, 0.024 in the high-risk group, all P > 0.05) were similar between the groups. HDL-C levels of the Arg/Gln carriers were significantly lower than those of Arg/Arg carriers in control group and in the high-risk group (all P < 0.05).</p><p><b>CONCLUSION</b>Arg/Gln carriers were associated lower HDL-C levels in Han Chinese.</p>
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Índice:
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Assunto principal:
Sangue
/
Polimorfismo de Fragmento de Restrição
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Fatores de Risco
/
Doença das Coronárias
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Povo Asiático
/
Etnologia
/
Grelina
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Frequência do Gene
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Genética
/
Genótipo
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2008
Tipo de documento:
Article