Fibrinolytic therapy for femoral artery thrombosis after left cardiac catheterization in children / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 518-521, 2010.
Article
em Zh
| WPRIM
| ID: wpr-244200
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The study was conducted to investigate the feasibility and effectiveness of fibrinolytic therapy for femoral artery thrombosis after left cardiac catheterization in children.</p><p><b>METHODS</b>Thrombolytic therapy with urokinase was applied in 16 children (5 males) with femoral artery thrombosis after left cardiac catheterization. Patients were given a bolus injection of heparin, 100 U/kg. 30,000-100,000 U boluses of urokinase were injected intravenously, and then a continuous infusion of 10,000-50,000 U/h was started. Transcatheter thrombolysis was performed once previous procedures failed.</p><p><b>RESULTS</b>All 16 patients presented lower limbs ischemia after left cardiac catheterizations. The age was (2.6 +/- 1.9) years, the height was (85.3 +/- 13.1) cm, the weight was (11.2 +/- 3.8) kg. Patients with cyanotic and acyanotic congenital heart disease were 2 and 14, respectively. Interventional therapy was performed in 12 patients. Absent arterial pulsations were found in 15 patients and reduced arterial pulsation in 1 patient. Femoral arterial perfusion became normal in all patients (3 after transcatheter thrombolysis, 11 post intravenous thrombolysis and 2 post intravenous heparin). The average doses of heparin and urokinase were (950 +/- 682) U and (295,357 +/- 198,770) U. The average duration of therapy was (7.25 +/- 5.31) h. Mild residual stenosis were found in 2 patients post various treatments.</p><p><b>CONCLUSION</b>Fibrinolytic therapy with urokinase is a safe and useful modality for children with femoral artery thrombosis after left cardiac catheterization.</p>
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Índice:
WPRIM
Assunto principal:
Complicações Pós-Operatórias
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Trombose
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Cateterismo Cardíaco
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Heparina
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Ativador de Plasminogênio Tipo Uroquinase
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Terapia Trombolítica
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Usos Terapêuticos
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Tratamento Farmacológico
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Artéria Femoral
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Fibrinolíticos
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2010
Tipo de documento:
Article